Cellulite Research Today is a free monthly online journal that collates and summarizes the latest research about Cellulite, including details on treatment, reduction, removal, cures. | ||||||||
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Muscle regeneration by adipose tissue-derived adult stem cells attached to injectable PLGA spheres.Kim M, Choi YS, Yang SH, Hong HN, Cho SW, Cha SM, Pak JH, Kim CW, Kwon SW, Park CJ Asan Institute for Life Sciences, University of Ulsan, Seoul, Republic of Korea. mjkimhsc@korea.com The [corrected] use of adult stem cells for cell-based tissue engineering and regeneration strategies represents a promising approach for skeletal muscle repair. We have evaluated the combination of adipose tissue-derived adult stem cells (ADSCs) obtained from autologous liposuction and injectable poly(lactic-co-glycolic acid) (PLGA) spheres for muscle regeneration. ADSCs attached to PLGA spheres and PLGA spheres alone were cultured in myogenic medium for 21 days and injected subcutaneously into the necks of nude mice. After 30 and 60 days, the mice were sacrificed, and newly formed tissues were analyzed by immunostaining, H and E staining, and RT-PCR. We found that ADSCs attached to PLGA spheres, but not PLGA spheres alone, were able to generate muscle tissue. These findings suggest that ADSCs and PLGA spheres are useful materials for muscle tissue engineering and that their combination can be used in clinical settings for muscle regeneration. Published 14 August 2006 in Biochem Biophys Res Commun, 348(2): 386-92.
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